Not to be understated in terms of potential severity, it is true that the number of penicillin 'allergic' patients far outnumbers the number of patients with an actual allergy to penicillin.
The validity of allergies to penicillin recorded in the chart is questionable. The JAMA classic article on history of pencillin allergy is here.
This study (and others) shows meropenem is *likely* safe in patients with IgE mediated penicillin allergy.
The following review article discusses the use of other agents and a strategy for evaluating patients with penicillin allergy. This review discusses antibiotic allergies in general.
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The ACLS guidelines for the management of anaphalaxis are here.
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