One of the complications of candidemia is the development of endogenous endopthalmitis. Different rates of occular involvement are quoted from 2%-40% depending on case series.
The majority of patients will develop endopthamitis within 2 weeks of candidemia. Particularly if there is a delay in treatment of the candidemia or if the candidemia is protracted.
Early retinal exam can diagnosis, but follow up at 2 weeks is prudent as early lesions can be missed.
Treatment is covered in the IDSA guidelines (previously cited). Azole agents can be used for succeptible isolates. If there is a significant vitritis, sometimes vitrectomy with intraoccular amphotericin is required in addition to systemic therapy.
There are a number of good reviews here (treatment), here (case report and review of condition), here (BMJ review) and here (retinal lesions in sepsis, including description of occular manifestations).
Treatment is covered in the IDSA guidelines (previously cited). Azole agents can be used for succeptible isolates. If there is a significant vitritis, sometimes vitrectomy with intraoccular amphotericin is required in addition to systemic therapy.
There are a number of good reviews here (treatment), here (case report and review of condition), here (BMJ review) and here (retinal lesions in sepsis, including description of occular manifestations).
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